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Savior sibling
A saviour baby or savior sibling (see spelling differences) is a child who is born to provide an organ or cell transplant to a sibling that is affected with a fatal disease, such as cancer or Fanconi anemia, that can best be treated by hematopoietic stem cell transplantation.
The savior sibling is conceived through in vitro fertilization. Fertilized zygotes are tested for genetic compatibility (human leucocyte antigen (HLA) typing), using preimplantation genetic diagnosis (PGD), and only zygotes that are compatible with the existing child are implanted. Zygotes are also tested to make sure they are free of the original genetic disease. The procedure is controversial.〔
==Indications==
A ''savior sibling'' may be the solution for any disease treated by hematopoietic stem cell transplantation. It is effective against genetically detectable (mostly monogenic) diseases, e.g. Fanconi anemia, Diamond-Blackfan anemia〔(SAVIOUR SIBLING ) worldwidewords.org. Page created 11 Aug. 2007〕 and β-thalassemia, in the ailing sibling, since the savior sibling can be selected to not have inherited the disease. The procedure may also be used in children with leukemia, and in such cases HLA match is the only requirement, and not exclusion of any other obvious genetic disorder.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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